1. Dio Brando from Jojo's Bizarre Adventure Part's 1 and 3
You didn't honestly think I'd forget Dio Brando did you? What did Dio do that could merit him as the best villain?
Let's see
Beat the living shit out of Jonathan several times
Burned Jonathan's Dog (Literally)
Forced himself on Jonathan's girlfriend
Kills his own father and attempts to kill Jonathan's
Becomes a Vampire
Creates several vampires
Turns the mother of a baby into a vampire and then she eats her baby's face like it was a cheese pizza
Kills Jonathan and steals his body
And that's just from Part 1.
This one bad ass motherfucker. He will make you run over people on the sidewalk. Why? Because he's Dio MOTHERFUCKING Brando! He can do whatever the fuck he wants to and you can't do shit about it!