First issue wasn't impressive, it starts with a flashback 11 months before the death of Peter and his aunt departing in a lab of Osborn's, an experiment with a new Spider trying to copy the Oz formula. Before or after the goblin? Octavius was mentioned as one of the staff members, so that means before the Goblin crap
Spider enters the bag of Prowler who steals money from Oscorp, Prowler is Miles uncle, the spider bites the kid's hand in the apartment of Prowler